Thursday, February 16, 2012

different types of mutations.

Sense Mutation: a single substitution mutation when the change in the DNA base sequence results in a new codon still coding for the same amino acid 

Non-sense Mutation: a codon that stands for an amino acid mutates to one of these three stop codons. Nonsense mutations cause the protein to be cut off early and therefore incomplete, which usually renders it non-functional.

Deletion Mutation: A type of gene mutation wherein the deletion (as well as addition) of (a number of) nucleotide(s) causes a shift in the reading frame of the codons in the mRNA, thus, may eventually lead to the alteration in the amino acid sequence at protein translation

Insertion Mutation: A type of mutation resulting from the addition of extra nucleotides in a DNA sequence or chromosome. Insertion of a larger segment into the chromosome can also lead to mutation. It results when an unequal crossover happens during meiosis. 

Frameshift Mutation: A mutation seen when a number of DNA nucleotides not divisible by three is added or deleted. This causes a reading frame shift and all of the codons and all of the amino acids after that mutation are usually wrong. 

Point Mutation:  A mutation in DNA or RNA molecule involving a change of only one nucleotide base. It is a simple change in one base of the gene sequence.

Translocation Mutation: Translocations are the transfer of a piece of one chromosome to a nonhomologous chromosome. Translocations are often reciprocal; that is, the two nonhomologues swap segments. 

 references: http://www.biology-online.org http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/Mutations.html http://www.genetichealth.com/g101_changes_in_dna.shtml

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